Clinical Chemistry in Diagnosis and Treatment (1994) Philip D Mayne

Call No: QY90 Z69 1994 

Author: Philip D. Mayne
Publisher: Oxford Univ Pr
Publication Date: 1994-01-01
Language: English
Format: Paperback
ISBN-10: 0340576472
ISBN-13: 9780340576472
Product ID: EPID48049310

Topics of interest

Chapter 11: Plasma Lipids and Lipoproteins (pages 223-241)
Terminology (page 224)
Plasma Lipids (pages 224-5)
- Fatty acids
- Triglycerides
- Phospholipids
- Cholesterol
- Fig 11.1: Chemical structure of lipids present in plasma
- Table 11.1: Fatty acids present in plasma


Lipoproteins (pages 225-6; 227)
- Chylomicrons
- VLDL
- IDL
- LDL
- HDL
- Table 11.2: The composition and electrophoretic mobility of the main lipoprotein particles
- Table 11.3: WHO (Fredrickson) classification of hyperlipidaemia, based on the electrophoretic pattern of the lipoproteins 
- Table 11.4: The main apolipoproteins and their known functions (page 227)
- Fig 11.2: Exogenous pathway of lipid metabolism (page 228)
- Fig 11.3: Endogenous pathway of lipid metabolism (page 229)
- Fig 11.4: The relation between the cellular uptake of LDL and the endogenous synthesis of cholesterol (page 230)


Metabolism of Lipoproteins (pages 227-231)
- Exogenous Lipid Pathways
- - Chylomicron Metabolism
- Endogenous Lipid Pathways
- - VLDL Metabolism
- - LDL Metabolism
- - Factors Influencing Plasma LDL Concentrations
- Role of HDL


Disorders of Lipid Metabolism (pages 232-236)
- Clinical Manifestation of Hyperlipidaemia
- - arterial walls, subcutaneous tissue, tendons, cornea
- Lipid and Cardiovascular Disease
- Predominant Hypercholesterolaemia
- - What is hypercholesterolaemia?
- - Causes of hypercholesterolaemia
- - - Secondary hypercholesterolaemia
- - - - Table 11.5: The effect of some drugs on plasma lipid concentrations
- - - Primary hypercholesterolaemia
- - - - Familial combined hyperlipidaemia
- - - - Familial (monogenic) hypercholesterolaemia
- Predominant Hypertriglyceridaemia
- - Table 11.6: Some important causes of secondary hypertriglyceridaemia
- - Familial combined hyperlipidaemia
- - Familial endogenous hypertriglyceridaemia
- Mixed Hyperlipidaemia
- Rare Disorders Associated With Lipid Metabolism


Principles of Treatment of Hyperlipidaemia (pages 236-7)
- General Measures
- - Hypercholesterolaemia
- - - Restriction of dietary animal fats, eggs and dairy products
- - - Drug treatment
- - Hypertriglyceridaemia
- - - Dietary restriction
- - - Fibric acid derivatives 


Summary (page 238)


Investigation of Lipid Disorders (pages 239-241)
- Plasma Sampling
- Investigation of Suspected Hyperlipidaemia
- Is The Cause Primary Or Secondary?
- What Is The Nature Of The Abnormality?
- Family Studies
- Treatment