ATP Production in Muscle

Musculoskeletal Block, MD Phase I 2011/2012

SLU: Energy Metabolism in Muscle - ATP production

Prepared by Dr Aini Suzana Adenan
17 October 2011


2. How many ATPs are produced in the catabolism of:

a. glucose to pyruvate?

b. glucose to carbon dioxide and water (complete oxidation) in liver and muscle?

c. glucose to lactate?

SLU: Energy Metabolism in Muscle - Oxidation of NADH and FADH2

Musculoskeletal Block, MD Phase I 2011/2012
Prepared by Dr Aini Suzana Adenan
17 October 2011

SLU
5. How many ATP molecules are produced in the oxidation of NADH and FADH2 through the electron transport chain (ETC)?

Professional I Exam 2 May 2011 (Part 3)

Biochemistry: Oxidative phosphorylation

Describe oxidative phosphorylation (10 minutes).

Guide to answering this question:

1. Which compartment? Mitochondria
2. What is it about? It involves the production of ATP in the mitochondria under aerobic conditions, with the simultaneous formation of water from oxygen and hydrogen. 
3. What are the necessary conditions? Aerobic
4. How does it happen/What are the reactions? Coupled reactions for the formation of ATP & water
5. What are the sources/feeders? For the hydrogens, it involves electrons passed down the electron transport chain (ETC) by reducing equivalents (NADH & FADH2) which enter the ETC to give their electrons.
6. What are the products? ATP and water
7. What is the purpose of this? Oxidative phosphorylation is the final stage of complete biological oxidation for the production of ATP. Water is the waste product, also cools down all the heat that comes from electrons passing through ETC.

Some relevant diagrams: