Showing posts with label catecholamine. Show all posts
Showing posts with label catecholamine. Show all posts

Saturday, 6 July 2013

Epinephrine (Adrenaline)

  1. Lipid mobilization.
  2. Glycogenolysis is stimulated by epinephrine and/or norepinephrine.
  3. Epinephrine (or adrenaline or adrenalin) is a hormone and a neurotransmitter. 
  4. Epinephrine has many functions in the body: regulating heart rate, blood vessel and air passage diameters, and metabolic shifts. 
  5. Epinephrine release is a crucial component of the fight-or-flight response of the sympathetic nervous system. 
  6. Epinephrine is one of a group of monoamines called the catecholamines. 
  7. Adrenaline is used to treat a number of conditions including: cardiac arrest, anaphylaxis, and superficial bleeding. 
  8. It has been used historically for bronchospasm and hypoglycemia. 
  9. Newer treatments for bronchospasm and hypoglycaemia, such as salbutamol, a synthetic epinephrine derivative, and dextrose, respectively, are currently preferred.
  10. Adrenaline is also used as a bronchodilator for asthma if specific β2 agonists are unavailable or ineffective.
  11. Adrenaline is used as a drug to treat cardiac arrest and other cardiac dysrhythmias resulting in diminished or absent cardiac output. Its actions are to increase peripheral resistance via α1receptor-dependent vasoconstriction and to increase cardiac output via its binding to β1 receptors.
  12. Due to its vasoconstrictive effects, adrenaline is the drug of choice for treating anaphylaxis. Allergy patients undergoing immunotherapy may receive an adrenaline rinse before the allergen extract is administered, thus reducing the immune response to the administered allergen.
  13. Adrenaline is added to injectable forms of a number of local anesthetics, such as bupivacaine and lidocaine, as a vasoconstrictor to slow the absorption and, therefore, prolong the action of the anesthetic agent. Due to epinephrine's vasoconstricting abilities, the use of epinephrine in localized anesthetics also helps to diminish the total blood loss the patient sustains during minor surgical procedures.

http://en.wikipedia.org/wiki/Epinephrine

Injectable epinephrine:
http://en.wikipedia.org/wiki/File:Adrenalin_Ampulle.jpg

Catecholamines:
http://en.wikipedia.org/wiki/Catecholamine

Thursday, 27 September 2012

Catecholamines


  1. Catecholamines are chemical compounds derived from the amino acid tyrosine (Tyr) that act as hormones or neurotransmitters. They are examples of phenethylamines.
  2. Catecholamines are soluble, and so they can circulate dissolved in blood.
  3. The most abundant catecholamines are epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. They are produced mainly from the adrenal medulla and the postganglionic fibres of the sympathetic nervous system.
  4. Adrenaline acts as a neurotransmitter in the central nervous system (CNS) and as a hormone in the blood circulation. 
  5. Noradrenaline is primarily a neurotransmitter of the peripheral sympathetic nervous system but is also present in the blood (mostly through "spillover" from the synapses of the sympathetic system).
  6. High catecholamine levels in blood are associated with stress. Catecholamines cause general physiological changes that prepare the body for physical activity (e.g. exercise). Some typical effects are increases in heart rate, blood pressure, and blood glucose levels. 
  7. Some drugs, like selegiline, raise the levels of all the catecholamines. Selegiline (l-deprenyl, Eldepryl® or Anipryl® [veterinary]) is a drug used for the treatment of early-stage Parkinson's disease and senile dementia


Selegiline