Cori Cycle

What is the Cori cycle? How is it important to metabolism?

1. The Cori cycle is also known as the lactic acid cycle.
2. The Cori cycle involves 2 organs, the contracting muscle and the liver.
3. It functions in anaerobic conditions when the muscles are contracting under reduced oxygen.
4. The contracting muscles produce lactate (instead of pyruvate proceeding to acetyl CoA to TCA cycle) which is supplied to the liver.
5. In the liver, gluconeogenesis converts lactate to pyruvate and glucose.
6. Glucose is then metabolised by contracting muscle via glycolysis, to pyruvate and acetyl CoA under aerobic condition (sufficient oxygen), and acetyl CoA enters TCA cycle. Otherwise the glucose goes through anaerobic glycolysis and the Cori cycle goes on till oxygen is sufficient.

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PowerPoints

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http://slideplayer.com/slide/4450545/

http://slideplayer.com/slide/3863013/