SGD: Enery Metabolism in Muscle - Inhibitors and mutations of ETC proteins

Musculoskeletal Block, MD Phase I 2011/2012
Prepared by Dr Aini Suzana Adenan
17 October 2011

SGD
7. Inhibitors of the electron transport chain proteins and mutations in the mitochondrial and nuclear DNA that encodes them can cause reduced activity of the electron transport chain. Explain why impairment of the electron transport chain can cause lactic acidosis.

SLU: Energy Metabolism in Muscle - Oxidation of NADH and FADH2

Musculoskeletal Block, MD Phase I 2011/2012
Prepared by Dr Aini Suzana Adenan
17 October 2011

SLU
5. How many ATP molecules are produced in the oxidation of NADH and FADH2 through the electron transport chain (ETC)?

Inhibitors & Uncouplers of ETC

Musculoskeletal Block, MD Phase I 2011/2012

SLU: Energy Metabolism in Muscle - Inhibitors and Uncouplers of ETC

Prepared by Dr Aini Suzana Adenan
17 October 2011


6. Which of the following is an inhibitor or uncoupler of the electron transport chain (ETC)? Explain their mechanism of action.

a. Cyanide (CN-)

b. Carbon monoxide (CO)

c. 2.4-Dinitrophenol (2,4-DNP)

d. Gramicidin