Clinical Chemistry in Diagnosis and Treatment (1994) Philip D Mayne

Call No: QY90 Z69 1994 

Author: Philip D. Mayne
Publisher: Oxford Univ Pr
Publication Date: 1994-01-01
Language: English
Format: Paperback
ISBN-10: 0340576472
ISBN-13: 9780340576472
Product ID: EPID48049310

Topics of interest

Chapter 10: Carbohydrate Metabolism (pages 195-222)
- Table 10.1: Common reducing and non-reducing sugars (page 196)

- The Importance of Extracellular Glucose Concentrations (page 196-7)
- Maintenance of Extracellular Glucose Concentrations (page 197)

- - Hormones concerned with glucose homeostasis (page 197)
- - - Insulin; Structure of proinsulin (Fig 10.1, page 197)
- - - Circulating C-peptide
- - - Glucagon
- - - Table 10.2: Action of hormones that affect intermediary metabolism (page 198)

- Control of plasma glucose concentration (page 198-9)
- - The Liver (page 198-200)
- - Fig 10.2: Postprandial metabolism of glucose (page 199)
- - Table 10.3: Metabolism of the carbon skeleton of some amino acids to either carbohydrate (glycogenic) or fat (ketogenic) (page 200)
- Systemic effects of a glucose load (page 200)

- Ketosis (pages 201-2)
- - Adipose Tissue and the Liver
- - Fig 10.3: Intermediary metabolism during fasting: ketosis (page 201)
- - Table 10.2: Action of hormones that affect intermediary metabolism (page 198)

- Lactate Production  and Lactic Acidosis (pages 202-5)
- - Striated muscle and the liver (page 202-3)
- - Fig 10.4: Intermediary metabolism during muscular contraction: the Cori cycle (page 203)
- - Pathological lactic acidosis (pages 203- 205)
- - Tissue hypoxia (pages 203-4)
- - Fig 10.5: Metabolic pathways during tissue hypoxia (page 204)

- Urinary Glucose (page 205)
- - Glycosuria
- - Reducing substances 
- - - Table 10.1: Common reducing and non-reducing sugars (page 196)
- - - Table 10.4: Reducing substances in urine ... (page 105) 


Hyperglycaemia and Diabetes Mellitus (pages 206-211)
- Diabetes mellitus
- Impaired Glucose Tolerance (IGT)
- Subjects as risk of developing diabetes mellitus (page 207)

- Clinical and Metabolic Features of IDDM (page 207)
- - Long-term effects

- Principles of Management of Diabetes Mellitus (pages 208)
- - Blood glucose concentrations
- - Glycated hemoglobin (HbA1c)


- Acute Metabolic Complications of Diabetes Mellitus (pages 208- 210)
- - Diabetic Ketoacidosis
- - Hyperosmolal Non-Ketotic Coma
- - Other causes of coma in patients with diabetes mellitus

- Principles of Treatment of Diabetic Coma (pages 210-211)
- - Diabetic ketoacidosis
- - Hyperosmolal nonketotic coma


- Hypoglycemia (page 211-212)
- - Table 10.6: Principal causes of fasting hypoglycaemia in adults
- - Table 10.7: Substances that may provoke hypoglycaemia


- Hypoglycaemia, Particularly in Adults (pages 212-213)
- - Insulin- or other drug-induced hypoglycaemia
- - - Table 10.8: Results of plasma insulin and C-peptide estimations during hypoglycaemia (spontaneous or after a prolonged fast)
- - Insulinoma (page 212-3)
- - Alcohol-induced hypoglycaemia
- - During prolonged fasting (page 213)
- - Non-pancreatic tumours
- - Reactive (functional) hypoglycaemia
- - Endocrine causes
- - Impaired liver function


- Hypoglycaemia in Infants and Chilldren (pages 213-5)
- - Neonatal Period
- - Early Infancy
- - - Glycogenoses
- - - Hereditary fructose intolerance
- - Later Infancy
- - - Idiopathic hypoglycaemia of infancy
- - - Leucine sensitivity


- Treatment of Hypoglycemia (page 215)
-  Summary (216)


- Investigation of Disorders of Carbohydrate Metabolism
- Estimation of Plasma or Blood Glucose
- Collection of Urine Sample for Glucose Estimation


Investigation of Suspected Diabetes Mellitus (pages 217-220)
- Initial investigations
- Table 10.10: Interpretation of fasting and random plasma glucose concentrations
- Oral Glucose Tolerance Test / OGTT (pages 218-219)
- Table 10.12: Interpretation of oral glucose tolerance (page 218)
- Initial investigation of a diabetic patient presenting in coma (page 219-220)
- Table 10.13: Clinical and biochemical features of a diabetic presenting in coma (page 219)


Investigations of Hypoglycaemia (pages 220-222)
- Insulin Suppression Test
- Glycosuria
- - Reducing substances 
- - - Glucose
- - - Glucuronates
- - - Galactaose
- - - Fructose
- - - Lactose
- - - Pentoses
- - - Homogentisic acid


- Ketonuria (page 222)