We cannot open a live human to study the reactions in the liver. A get-around solution is to use liver models.
The liver model is used to study liver metabolism in liver disease and rare inborn errors of metabolism (IEM) that involve the liver. The liver model uses a tissue specific and disease specific model-based algorithm (MBA):
The content of the input and output sets of MBA are reactions, metabolites, genes and pathways for a generic model and a liver model.
The MBA also uses several parameters, including data from other research fields:
Metabolomics
Transcriptomics
Proteomics
Phenotypic data
Some of the pathways and diseases which can be studied using the liver model are:
External link
http://www.nature.com/msb/journal/v6/n1/full/msb201056.html
The liver model is used to study liver metabolism in liver disease and rare inborn errors of metabolism (IEM) that involve the liver. The liver model uses a tissue specific and disease specific model-based algorithm (MBA):
The content of the input and output sets of MBA are reactions, metabolites, genes and pathways for a generic model and a liver model.
The MBA also uses several parameters, including data from other research fields:
Metabolomics
Transcriptomics
Proteomics
Phenotypic data
Some of the pathways and diseases which can be studied using the liver model are:
- Gluconeogenesis
- Ammonia metabolism
- Urea cycle
- Obesity
- Diabetes
External link
http://www.nature.com/msb/journal/v6/n1/full/msb201056.html
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